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	renal hypertension

Disease ID	1116
Disease	renal hypertension
Definition	Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.
Synonym	hypertension renal hypertension, renal hypertension, renal [disease/finding] hypertensions, renal renal hypertension (disorder) renal hypertensions
DOID	DOID:1073
UMLS	C0020544
MeSH	D006977
SNOMED-CT	SNOMEDCT_US_2016_09_01:28119000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:15) C0242231 \| coronary stenosis \| 2 C0035078 \| renal failure \| 1 C0004153 \| atherosclerosis \| 1 C0022661 \| chronic renal failure \| 1 C0002871 \| anemia \| 1 C0020295 \| hydronephrosis \| 1 C0007222 \| cardiovascular diseases \| 1 C0011860 \| type 2 diabetes \| 1 C0007134 \| renal cell carcinoma \| 1 C0022116 \| ischaemia \| 1 C0003850 \| arteriosclerosis \| 1 C0042373 \| vascular diseases \| 1 C0007222 \| cardiovascular disease \| 1 C0011847 \| diabetes \| 1 C0042373 \| vascular disease \| 1
Curated Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 4878 \| NPPA \| CTD_human 183 \| AGT \| CTD_human 4627 \| MYH9 \| CTD_human
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:10) 1636 \| ACE \| CIPHER 183 \| AGT \| CIPHER;CTD_human 185 \| AGTR1 \| CIPHER 1559 \| CYP2C9 \| CIPHER 1812 \| DRD1 \| CIPHER 2868 \| GRK4 \| CIPHER 9027 \| NAT8 \| CIPHER 4846 \| NOS3 \| CIPHER 4878 \| NPPA \| CTD_human 4627 \| MYH9 \| CTD_human
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:63) 153 \| ADRB1 \| 3.998 \| DISEASES 183 \| AGT \| 3.318 \| DISEASES 186 \| AGTR2 \| 3.446 \| DISEASES 23365 \| ARHGEF12 \| 2.624 \| DISEASES 10159 \| ATP6AP2 \| 1.716 \| DISEASES 551 \| AVP \| 2.446 \| DISEASES 567 \| B2M \| 1.405 \| DISEASES 144453 \| BEST3 \| 1.349 \| DISEASES 653 \| BMP5 \| 1.017 \| DISEASES 153571 \| C5orf38 \| 2.244 \| DISEASES 10203 \| CALCRL \| 1.354 \| DISEASES 959 \| CD40LG \| 1.153 \| DISEASES 1490 \| CTGF \| 1.53 \| DISEASES 5476 \| CTSA \| 1.341 \| DISEASES 1536 \| CYBB \| 1.931 \| DISEASES 1585 \| CYP11B2 \| 1.002 \| DISEASES 1621 \| DBH \| 1.52 \| DISEASES 1667 \| DEFA1 \| 1.202 \| DISEASES 728358 \| DEFA1B \| 1.202 \| DISEASES 1665 \| DHX15 \| 1.473 \| DISEASES 50506 \| DUOX2 \| 1.362 \| DISEASES 1896 \| EDA \| 1.038 \| DISEASES 1906 \| EDN1 \| 3.593 \| DISEASES 23085 \| ERC1 \| 1.309 \| DISEASES 51218 \| GLRX5 \| 1.264 \| DISEASES 2873 \| GPS1 \| 1.166 \| DISEASES 2868 \| GRK4 \| 1.751 \| DISEASES 9365 \| KL \| 1.879 \| DISEASES 55554 \| KLK15 \| 1.866 \| DISEASES 9622 \| KLK4 \| 3.768 \| DISEASES 10724 \| MGEA5 \| 2.709 \| DISEASES 4336 \| MOBP \| 1.365 \| DISEASES 136319 \| MTPN \| 1.377 \| DISEASES 200958 \| MUC20 \| 1.665 \| DISEASES 4624 \| MYH6 \| 1.501 \| DISEASES 4763 \| NF1 \| 2.001 \| DISEASES 4842 \| NOS1 \| 1.076 \| DISEASES 7827 \| NPHS2 \| 1.509 \| DISEASES 4878 \| NPPA \| 2.064 \| DISEASES 4306 \| NR3C2 \| 1.291 \| DISEASES 4923 \| NTSR1 \| 1.173 \| DISEASES 197135 \| PATL2 \| 3.298 \| DISEASES 10015 \| PDCD6IP \| 1.518 \| DISEASES 5154 \| PDGFA \| 1.761 \| DISEASES 8504 \| PEX3 \| 1.489 \| DISEASES 5251 \| PHEX \| 1.151 \| DISEASES 389362 \| PSMG4 \| 2.346 \| DISEASES 5733 \| PTGER3 \| 1.038 \| DISEASES 5743 \| PTGS2 \| 1.984 \| DISEASES 83871 \| RAB34 \| 2.144 \| DISEASES 25898 \| RCHY1 \| 4.431 \| DISEASES 387 \| RHOA \| 1.104 \| DISEASES 8710 \| SERPINB7 \| 1.146 \| DISEASES 6565 \| SLC15A2 \| 1.238 \| DISEASES 387775 \| SLC22A10 \| 2.532 \| DISEASES 6525 \| SMTN \| 1.799 \| DISEASES 6696 \| SPP1 \| 1.395 \| DISEASES 81551 \| STMN4 \| 1.368 \| DISEASES 56670 \| SUCNR1 \| 2.163 \| DISEASES 11346 \| SYNPO \| 1.139 \| DISEASES 26136 \| TES \| 1.138 \| DISEASES 7054 \| TH \| 1.433 \| DISEASES 7296 \| TXNRD1 \| 1.239 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1116
Disease	renal hypertension
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:9) HP:0002621 \| Atherosclerosis \| 1 HP:0002634 \| Arteriosclerosis \| 1 HP:0000126 \| Hydronephrosis \| 1 HP:0000074 \| Ureteropelvic junction obstruction \| 1 HP:0030731 \| Carcinoma \| 1 HP:0001903 \| Anemia \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0005584 \| Renal cell carcinoma \| 1 HP:0000083 \| Renal insufficiency \| 1

Disease ID	1116
Disease	renal hypertension
Manually Symptom	UMLS \| Name(Total Manually Symptoms:8) C2712322 \| tachycardia C1332965 \| congenital mesoblastic nephroma C0221755 \| abdominal bruit C0085413 \| adult polycystic kidney disease C0042341 \| varicocele C0038454 \| apoplexy C0027051 \| myocardial infarct C0022679 \| cystic kidney
Text Mined Symptom	(Waiting for update.)

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:3)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs4961	12172317	1585	CYP11B2	umls:C0020544	BeFree	In a Caucasian population, the prevalence and incidence of hypertension, renal function and large artery stiffness were significantly correlated with polymorphisms in the genes encoding the angiotensin-converting enzyme (ACE I/D), aldosterone synthase (-C344T) and the cytoskeleton protein alpha-adducin (Gly460Trp).	0.002638474	2002	ADD1	4	2904980	G	T
rs4961	12172317	118	ADD1	umls:C0020544	BeFree	In a Caucasian population, the prevalence and incidence of hypertension, renal function and large artery stiffness were significantly correlated with polymorphisms in the genes encoding the angiotensin-converting enzyme (ACE I/D), aldosterone synthase (-C344T) and the cytoskeleton protein alpha-adducin (Gly460Trp).	0.000271442	2002	ADD1	4	2904980	G	T
rs4961	12172317	1636	ACE	umls:C0020544	BeFree	In a Caucasian population, the prevalence and incidence of hypertension, renal function and large artery stiffness were significantly correlated with polymorphisms in the genes encoding the angiotensin-converting enzyme (ACE I/D), aldosterone synthase (-C344T) and the cytoskeleton protein alpha-adducin (Gly460Trp).	0.00973957	2002	ADD1	4	2904980	G	T

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1116
Disease	renal hypertension
Case	(Waiting for update.)

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